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                Cell Growth and Differentiation | Cell Culture Applications | Corning

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                Enhance cell culture and accelerate discovery

                Several major classes of molecules regulate cellular development and function, including growth and differentiation factors, cell adhesion molecules, and the components of the extracellular matrix (ECM). The ECM is composed of a number of different macromolecules that influence such cell behaviors as adherence, spreading, differentiation, and migration. It also influences the pattern of gene expression of the cells in which it is in contact. To create physiologically relevant in vitro models that support normal cell growth and function, the components of the in vivo environment must be incorporated. Using ECM proteins as a coating for tissue culture surfaces permits the development of cell type-specific model systems that closely mimic in vivo conditions.

                To help you take full advantage of the vital role ECMs play in the regulation of fundamental cellular processes, Corning offers a wide range of extracellular matrix proteins and attachment factors, including Corning® Matrigel® matrix, Corning BioCoatTM cellware, and other Corning ECM surfaces. Discover how these can be incorporated into your cell culture systems to support advanced cell growth and cell differentiation applications. 

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                Applications

                Human Embryonic Stem Cells

                Human Embryonic Stem Cells

                Save time and resources normally spent qualifying reagents by creating a culture environment for human embryonic stem cells (hESCs) consisting of both a serum-free, defined medium and cell culture surface specifically qualified for hESCs cells. For example, Matrigel matrix, coupled with a variety of culture media, has been widely accepted as an alternative substrate to feeder-dependent culture of hESCs, and it has been used to culture induced pluripotent stem (iPS) cells.

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                Technical Documents

                Validation and Application Support for Stem Cell

                Applications

                Cancer Cells

                Cancer Cells

                Cancer cells exhibit altered cellular functions compared to the normal functioning, non-malignant cells from which they are derived. The hallmark of metastatic cells is their ability to invade through the basement membrane and migrate to other parts of the body. From cell culture reagents such as Matrigel high concentration to membrane insert systems, like Falcon® permeable supports , discover how Corning cell culture products can help you gain greater insights into tumor cell growth, morphology, and migration.

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                Technical Documents

                Validation and Application Support for Cell Growth

                Cell Migration, Chemotaxis, and Invasion Assay Protocol

                Cell Migration, Chemotaxis, and Invasion Assay

                Successfully conduct a cell invasion assay through a basement membrane extract (BME) barrier, along with a chemotaxis assay, using Corning 96-well HTS Transwell® permeable support inserts.

                Successfully conduct a cell invasion assay through a basement membrane extract (BME) barrier, along with a chemotaxis assay, using Corning 96-well HTS Transwell® permeable support inserts.

                Methods for Implantation of Corning Matrigel Matrix into Mice and Tissue Fixation

                Methods for Implantation of Corning Matrigel

                This technical report supports the use of Matrigel matrix for such in vivo applications as angiogenesis and human tumor cell implantation in mice.

                This technical report supports the use of Matrigel matrix for such in vivo applications as angiogenesis and human tumor cell implantation in mice.

                Screening of Anti-metastatic Compounds by a Fluorescence-based Tumor Cell Invasion Assay

                Screening of Anti-metastatic Compounds

                Discovery of new cancer therapeutics has been constrained by the lack of reliable, high throughput primary and secondary biological assays. To address this need, Corning developed the FluoroBlok™ 24-multiwell insert system. This brief provides detailed technical information on the performance of this quantitative, automation-compatible, fluorescence-based tumor cell invasion assay system for high throughput applications.

                Discovery of new cancer therapeutics has been constrained by the lack of reliable, high throughput primary and secondary biological assays.

                Applications

                Neuronal Cells

                Neuronal Cells

                Neurobiology is a rapidly evolving field that encompasses a variety of cell types, including neurons and neuronal stem cells. In vitro culture of such diverse cell types requires appropriate culture surfaces for attachment and proliferation/differentiation. From innovative surfaces such as Corning BioCoat cellware  to Tissue Culture-treated vessels, such as Falcon flasks, learn how you can more effectively grow and differentiate neuronal cells using compatible surfaces for 2D and 3D culture applications.

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                Technical Documents

                Validation and Application Support

                Applications

                Epithelial Cells

                Epithelial Cells

                The interactions between the epithelial cell and matrix proteins effect cell morphology and function. In vitro, 2D and 3D culture systems can be used to study different aspects of cell growth and differentiation. 2D culture systems are used for cell attachment and proliferation. 3D environments are utilized in studies requiring a more in vivo-like setting. From BioCoat cell cultueware to Matrigel matrix, find out how Corning products can help enhance your 2D and 3D endothelial cell culture applications.

                Applications

                Hepatocytes

                Hepatocytes

                Improve the success of hepatocyte cell culture and differentiation with such Corning offerings as Collagen I, Matrigel matrix, PuraMatrixTM, and BioCoat Collagen cultureware. Cells cultured on these surfaces maintain their biological activity, and depending on the goals of the experiment, they can each enhance the differentiation and morphology of your specific culture application.

                Applications

                Cell Therapy

                Cell Therapy

                Our single-use adherent and suspension cell culture products provide reliable, predictable scale-up for cell therapy.  Scale-up cells in defined conditions, while reducing contamination and minimizing your footprint using advanced validated stacked surface solutions from Corning.

                Products

                Complete Solutions to Get Your Culture Right

                Vessels

                Vessels

                Rely on innovative vessels from Corning for quality and consistency in your cell growth and differntiation applications.

                Rely on innovative vessels from Corning for quality and consistency in your cell growth and differntiation applications.

                Surfaces

                Surfaces

                Look to Corning for the right surface for every cell—from biological to synthetic—we have a cell culture environment that meets your exact research requirements.

                Look to Corning for the right surface for every cell—from biological to synthetic—we have a cell culture environment that meets your exact research requirements.

                Media

                Media

                To maximize cell yield, choose from our comprehensive line of standard and custom culture media, including basal salt solutions, antibiotics, sera, and specialty media.

                To maximize cell yield, choose from our comprehensive line of standard and custom culture media, including basal salt solutions, antibiotics, sera, and specialty media.

                Resources

                Cell Growth and Differentiation Application Library

                Cell Growth and Differentiation Application

                From product selection guides to application notes to validation documents, our online technical library is available anytime you need to facilitate your cell growth and differentiation applications.

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